5F-ADB-PINACA

 

Understanding 5F-ADB-PINACA: A Comprehensive Overview

5F-ADB-PINACA is a synthetic cannabinoid, a class of laboratory-made chemicals designed to mimic the effects of delta-9-tetrahydrocannabinol (THC), the active component in cannabis. First identified in the mid-2010s, this compound has gained notoriety due to its potent psychoactive properties and links to numerous public health incidents. Order Now

This article offers a deep dive into its chemical structure, pharmacology, effects, recommended dosages, analogues, safety concerns, and a concluding perspective.

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Chemical Structure

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IUPAC Name:
N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide

Molecular Formula:
C19H26FN3O3

Molecular Weight:
363.43 g/mol

Structure Overview:
The cannabinoid features an indazole core attached to a 5-fluoropentyl chain at the nitrogen atom and a carboxamide linker bonded to a tert-leucine-derived side chain. The addition of a fluorine atom at the terminal position of the pentyl chain enhances its lipophilicity and receptor binding affinity.

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Pharmacology

This cannabinoid acts primarily as a full agonist at CB1 and CB2 cannabinoid receptors, which are part of the human endocannabinoid system.

• CB1 receptors: Located mainly in the central nervous system, responsible for psychoactive effects.
• CB2 receptors: Predominantly in peripheral tissues, especially immune cells.

Binding Affinity:
It exhibits high nanomolar to sub-nanomolar binding affinities, making it significantly more potent than natural THC.

Mechanism of Action:
Once ingested or inhaled, It binds to cannabinoid receptors, triggering effects on mood, perception, pain modulation, appetite, and memory. Due to its full agonist nature, it can produce much stronger and sometimes dangerous effects compared to partial agonists like THC.

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Effects

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Desired Effects:

• Intense euphoria
• Sedation
• Altered sensory perception
• Increased appetite

Adverse Effects:

• Severe anxiety and paranoia
• Hallucinations
• Nausea and vomiting
• Tachycardia (increased heart rate)
• Seizures
• Acute psychosis
• Loss of consciousness

Numerous hospitalizations and fatalities have been linked to this compound due to its extreme potency and unpredictable effects.

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Dosage and Administration

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Note: This cannabinoid is not approved for human consumption and lacks any medically recommended dosage.

Reported Routes of Administration:

• Smoking (herbal mixtures)
• Vaporizing
• Oral ingestion (rare)

Dosage:
Because of its potency, even microgram quantities can produce strong effects. Most adverse cases are linked to unregulated, unknown dosages within herbal incense or e-liquid products.

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Analogues and Related Compounds

The cannabinoid belongs to a broader family of indazole-based synthetic cannabinoids. Related compounds include:

• 5F-ADB (5F-MDMB-PINACA) — A closely related, highly potent synthetic cannabinoid.
• ADB-FUBINACA
• MDMB-CHMICA
• 5F-PB-22
• AB-FUBINACA

These analogues share similar core structures and pharmacological profiles but differ in their terminal alkyl or fluorinated groups, affecting potency and metabolic stability.

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Safety Considerations

Health Risks:

• High overdose potential due to extreme potency.
• Increased risk of cardiovascular events, seizures, and death.
• Impairment of judgment and psychomotor skills.
• Potential for dependence and withdrawal symptoms.

Legal Status:
Many countries and regions have placed 5F-ADB-PINACA under controlled substance laws. It is typically classified under Schedule I or equivalent due to its lack of medical use and high abuse potential.

Toxicological Profile:
Cases of intoxication often present with:

• Elevated heart rate
• Hypertension
• Confusion
• Loss of consciousness
• Acute kidney injury
• Multi-organ failure in severe instances

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Conclusion

5F-ADB-PINACA represents a dangerous chapter in the evolution of synthetic cannabinoids. While structurally crafted to mimic natural THC, its chemical modifications result in a far more potent and unpredictable profile. The lack of quality control in illicit markets and the compound’s severe health risks have made it a focal point for regulatory agencies and public health officials.

Anyone encountering substances suspected of containing 5F-ADB-PINACA should exercise extreme caution, as even minimal exposure can lead to life-threatening consequences. Its use in recreational settings is strongly discouraged.

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Disclaimer:
This article is intended for informational and educational purposes only. 5F-ADB-PINACA is a highly dangerous substance, and its possession, use, or distribution may be illegal in your jurisdiction. Always refer to local laws and regulations.