3-CEC (3-Chloroethcathinone)

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An Overview of 3-CEC Chemical: Structure, Pharmacology, Effects, and Safety

Introduction

3-CEC (3-Chloroethcathinone) is a synthetic stimulant belonging to the cathinone class of chemicals. These compounds are structurally related to cathinone, a naturally occurring stimulant found in the khat plant (Catha edulis). In recent years, 3-CEC has surfaced in online research chemical markets and is often categorized as a designer drug due to its psychoactive properties and structural similarity to controlled substances.

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Chemical Structure

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• IUPAC Name: 1-(3-chlorophenyl)-2-(ethylamino)propan-1-one
• Chemical Formula: C11H14ClNO
• Molecular Weight: 211.69 g/mol
• Structure Type: β-keto amphetamine (a substituted cathinone)

The molecule consists of a 3-chlorophenyl ring attached to a β-ketone group, with an ethylamino side chain. This configuration is structurally similar to 3-MMC (3-Methylmethcathinone), with the difference being a chlorine atom substituting the methyl group on the aromatic ring.

Structural Diagram (Textual):

    Cl
    |
C6H4-C-CO-CH(NHCH2CH3)

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Pharmacology

As a synthetic cathinone, 3-CEC acts primarily as a central nervous system (CNS) stimulant. Its mechanism of action is believed to involve:

• Releasing neurotransmitters like dopamine, norepinephrine, and serotonin.
• Blocking the reuptake of these neurotransmitters by interacting with transporter proteins.

This leads to elevated extracellular concentrations of these monoamines in the brain, contributing to its stimulating and euphoric effects.

However, precise pharmacological data on 3-CEC is limited due to the scarcity of formal studies and its recent emergence in the market.

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Effects

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While individual responses may vary, reported effects of 3-CEC typically include:

Positive Effects:

• Increased energy and stimulation
• Enhanced sociability and talkativeness
• Elevated mood and mild euphoria
• Heightened sensory perception

Neutral or Negative Effects:

• Jaw clenching and teeth grinding (bruxism)
• Increased heart rate and blood pressure
• Mild anxiety or agitation
• Insomnia and restlessness

Severe Adverse Effects (at high doses or in sensitive individuals):

• Cardiovascular stress
• Paranoia or hallucinations
• Risk of serotonin syndrome when combined with other substances

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Dosage and Administration

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As an unregulated research chemical, no official dosage guidelines exist for 3-CEC. Reports from user forums and anecdotal experiences suggest the following oral dosages:

• Threshold: 10–20 mg
• Light: 20–50 mg
• Common: 50–100 mg
• Strong: 100–150+ mg

Onset: 20–40 minutes (oral)
Duration: 3–5 hours (primary effects)
After-effects: Up to 8 hours

Note: Intranasal and other routes have been reported but increase the risk of adverse effects.

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Analogues and Related Compounds

3-CEC belongs to a family of cathinones with structural analogues, including:

• 3-MMC (3-Methylmethcathinone)
• 4-CEC (4-Chloroethcathinone)
• 4-MMC (Mephedrone)
• NEP (N-Ethyl-Pentedrone)

These compounds share similar stimulant and empathogenic properties but vary in potency, duration, and safety profiles.

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Safety Considerations

Due to its unregulated status and limited research:

• Toxicity data is lacking — potential neurotoxicity and cardiotoxicity cannot be ruled out.
• Risk of addiction and compulsive redosing exists.
• Drug interactions, especially with other stimulants or serotonergic substances, increase the danger of adverse reactions.
• Use of harm reduction practices such as reagent testing and precise dosing is strongly recommended for any research context.

Legal status varies globally; many jurisdictions have outlawed cathinone analogues or placed them under temporary bans.

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Conclusion

3-CEC is a synthetic cathinone that mimics the stimulant and euphoric effects of other well-known substances in its class. While it has gained attention in the research chemical scene, its pharmacological profile, toxicity, and long-term health risks remain largely unknown. As with all designer drugs, extreme caution, responsible research practices, and awareness of legal restrictions are essential.

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