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Mescaline: A Comprehensive Overview

Introduction

Mescaline is a naturally occurring psychedelic alkaloid primarily found in cacti such as Peyote (Lophophora williamsii), San Pedro (Echinopsis pachanoi), and Peruvian Torch (Echinopsis peruviana). It is one of the oldest known hallucinogenic substances, with a history of use in Native American spiritual and medicinal practices for centuries. Chemically classified as a phenethylamine, mescaline produces profound alterations in perception, mood, and cognition.

Qualities and Features

Chemical Properties

• IUPAC Name: 3,4,5-Trimethoxyphenethylamine
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.26 g/mol
• Melting Point: 35-36°C (freebase), 180-181°C (hydrochloride salt)
• Solubility: Soluble in water, alcohol, and organic solvents

Pharmacological Effects

Mescaline primarily exerts its psychoactive effects by acting as an agonist of the serotonin 5-HT₂A receptor. This leads to alterations in neurotransmission that result in visual hallucinations, enhanced colors, intensified emotions, altered time perception, and deep introspection. Some users report experiencing synesthesia, euphoria, and spiritual insights, while others may have anxiety or paranoia.

Onset and Duration

• Onset: 30 to 60 minutes
• Peak Effects: 2 to 4 hours after ingestion
• Total Duration: 8 to 12 hours
• Aftereffects: Mild cognitive changes for up to 24 hours

Analogs and Related Compounds

Mescaline is structurally similar to other psychedelic phenethylamines and substituted amphetamines, including:

• 4-HO-Mescaline: A hydroxy derivative with stronger psychedelic effects.
• 3C-P: A synthetic mescaline analog with longer-lasting effects.
• DOB (2,5-Dimethoxy-4-bromoamphetamine): A more potent and long-lasting psychedelic.
• 2C-B (4-Bromo-2,5-dimethoxyphenethylamine): A shorter-acting psychedelic with both stimulant and hallucinogenic properties.

Usage Instructions

Dosage

The potency of mescaline depends on whether it is consumed in pure form, cactus extract, or raw plant material. A general dosage guideline is:

• Threshold Dose: 50-100 mg
• Low Dose: 100-200 mg
• Common Dose: 200-400 mg
• High Dose: 400-600 mg
• Heavy Dose: 600+ mg

When consuming raw cacti, doses typically range from 20 to 50 grams of dried material or 200 to 500 grams of fresh cactus.

Method of Administration

• Oral Ingestion: The most common method, either in capsule form, powder, or tea made from boiled cactus.
• Sublingual Absorption: Some users let extracts dissolve under the tongue for faster absorption.

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Safety Precautions

• Avoid mixing with stimulants or depressants such as alcohol or amphetamines.
• Stay hydrated and consume in a comfortable, safe environment.
• Have a trusted sitter if inexperienced with psychedelics.
• Individuals with mental health conditions such as schizophrenia should avoid use due to the risk of exacerbating symptoms.

Legal Status

Mescaline is classified as a Schedule I substance in the U.S., meaning it is illegal for recreational use. However, some Indigenous groups, such as the Native American Church, are legally permitted to use peyote for religious ceremonies. In certain countries, mescaline-containing cacti are legal for cultivation and ornamental purposes but not for consumption.

Conclusion

Mescaline remains a powerful and historically significant psychedelic, offering unique spiritual and introspective experiences. While it has potential therapeutic applications in treating depression, PTSD, and addiction, research remains limited due to its legal restrictions. Responsible use, proper set and setting, and adherence to safety guidelines are essential for those exploring its effects.

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pschychodeledelen hormone that can be obtained from the little, spineless Pеуоte (Lорhорhоra wĖllіаmѕі), the San Pedro calves, the Peruvian tortch calves, and other containing calves. It can also be produced synthetically and is present in certain members of the family Fabаceae (bean family).

Natural occurrences of it include the peyote (Lорhорhоrа wĖllіаmѕіі),[1] the San Pedro (EchĖnорѕіѕ pachanoi), the Peruvian trochanter (EchĖnорѕіѕ peruviana), and more members of the plant family Cactaceae. Limited quantities in specific members of the beaan family, Fabaceae, which includes Acacia brеndĖеrѕ.

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For hundreds of years, people have used hallucinogens, usually for religious rituals or rites. Melancholy causes distorted visual hallucinations.

Native people have been using potatoes since ancient times in northern Mexico and the southwestern United States are considered traditional regions. It has an effect akin to that of LSD or psilocybin (magic mushrooms), other hallucinogenic drugs.