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5Mapb, or 5-(2-methylaminopropyl) benzofuran, is a synthetic empathogenic drug that is structurally related to MDMA (Ecstasy) and is classified as a research chemical. Researchers recognize that 5MAPB produces effects such as euphoria, emotional openness, empathy, and increased sociability. Although they have not extensively studied 5MAPB, some studies suggest its potential therapeutic uses in treating conditions like depression and anxiety. However, scientists must conduct more research to fully understand its effects and potential risks.

It is important to note that the use of 5-MAPB carries risks, including potential adverse effects on physical and mental health, as well as the risk of addiction and overdose. Shop Now

5-MAPB (5-(2-Methylaminopropyl)benzofuran) is a synthetic entactogen belonging to the substituted benzofuran class, structurally related to MDMA (3,4-methylenedioxy-N-methylamphetamine). It has gained attention for its psychoactive properties, including euphoria, empathy enhancement, and mild stimulation.

Chemical Structure and Properties

Chemically, 5-MAPB consists of a benzofuran ring fused to an N-methylated ethylamine chain, making it a derivative of methamphetamine. The oxygen atom in the furan ring occupies the 5-location on the benzene ring, influencing its pharmacological effects. This structural configuration contributes to its entactogenic and stimulant properties.

Pharmacology and Mechanism of Action

5-MAPB functions primarily as a triple monoamine reuptake inhibitor, affecting serotonin, dopamine, and norepinephrine levels in the brain. Additionally, it acts as an agonist at the 5-HT₂A and 5-HT₂B receptors. These actions result in increased concentrations of these neurotransmitters in the synaptic cleft, leading to its characteristic psychoactive effects.

Analogues and Related Compounds of 5Mapb Benzofuran

Several compounds are structurally and pharmacologically related to 5-MAPB:

• 5-APB (5-(2-Aminopropyl)benzofuran): Similar in structure but lacks the N-methyl group, leading to differences in potency and duration of effects.
• 6-APB (6-(2-Aminopropyl)benzofuran): The furan ring is attached at the 6-position, resulting in a distinct pharmacological profile.
• BK-5-MAPB (β-Keto-5-MAPB): Incorporates a β-ketone group, aligning it with substituted cathinones like methylone. It acts as a monoamine releaser with a potency comparable to MDMA.

Usage and Dosage

*Note: The following information is for educational purposes only and does not constitute medical advice.*

People typically administer 5-MAPB orally. Dosage guidelines based on user reports suggest:

• Threshold: 20 mg
• Light: 40–60 mg
• Common: 60–80 mg
• Strong: 80–100 mg
• Heavy: 100 mg and above

The total duration of effects ranges from 5 to 8 hours, with an onset of 20 to 60 minutes. Users may experience a peak lasting 2 to 4 hours, followed by an offset period of 1.5 to 3 hours. After-effects can persist for 6 to 48 hours.

Safety and Toxicity

Due to limited research, the safety profile of 5-MAPB is not well-established. Reported adverse effects include hypertension, tachycardia, hyperthermia, agitation, hallucinations, and, in severe cases, convulsions and elevated creatine kinase levels, indicating potential for serotonin toxicity. A documented case highlighted a 24-year-old male who exhibited these symptoms following 5-MAPB ingestion; symptoms resolved with aggressive symptomatic treatment.

Legal Status

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The legal status of 5-MAPB varies by country:

• United Kingdom: Class B controlled substance.
• United States: Not specifically scheduled, but may be considered an analogue of MDA, potentially subjecting it to regulation under the Federal Analogue Act.
• Canada: Not explicitly listed in the Controlled Drugs and Substances Act but could be deemed illegal due to structural similarities to MDMA.
• China: Controlled substance as of October 2015.
• Luxembourg: Not listed as a prohibited substance as of July 2021.

Conclusion

5-MAPB is a synthetic entactogen with psychoactive effects similar to MDMA. Its use is associated with significant risks, including severe adverse effects and potential legal consequences. Due to the limited understanding of its safety profile and pharmacological properties, caution is advised, and further research is necessary to fully comprehend its impact on human health.