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Due to 5-MAPB Powder being an agonist to the 2C receptor it would be appropriate to begin research by using this 2C receptor infused on a synthetic membrane. As 5-MAPB is so new it would be useful to publish the selectivity it has for this receptor by performing a receptor mapping study using a radiolabeled version of 5-MAPB. Further studies could include competitive ligand binding assays with other 2C ligands. It may only be used for in vitro (outside living organism) research unless a specific home office license is held.
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This Chemical may be used for primary reagent testing, as well as a reference sample for analytical libraries, such as GC/MS, HPLC, NMR, and FTIR analysis. Toxicologists and forensic scientists may utilize these chemical analyses. A (5-(2-methylaminopropyl)benzofuran) is a synthetic entactogen belonging to the substituted benzofuran class, structurally related to MDMA (3,4-methylenedioxymethamphetamine). It has been recognized for producing effects similar to MDMA, including euphoria, increased sociability, and enhanced sensory perception.
Chemical Structure and Properties
Chemically, 5-MAPB is the N-methylated derivative of 5-APB, analogous to the relationship between MDMA and MDA. Its molecular formula is C12H15NO, with a molecular weight of 189.25 g/mol in its freebase form.
Pharmacology
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5-MAPB functions primarily as a serotonin-norepinephrine-dopamine releasing agent, with notable affinity for serotonin transporters. It also acts as a partial agonist at the 5-HT2A, 5-HT2B, and 5-HT2C receptors. These interactions contribute to its entactogenic and stimulant properties.
Effects
Users have reported that it induces mood elevation, euphoria, increased sociability, and enhanced sensory perception. Physiological effects may include pupil dilation, increased heart rate, and mild stimulation. Some individuals have experienced adverse effects such as jaw tension, anxiety, and nausea, particularly at higher doses.
Dosage and Administration
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Due to limited research and the potential for significant variability in individual responses, precise dosing guidelines for 5-MAPB are not well-established. It is typically administered orally, with onset of effects occurring within 20 to 60 minutes and lasting approximately 3 to 6 hours. Given the lack of comprehensive safety data, caution is advised, and the compound should not be used without appropriate medical supervision.
Analogues and Related Compounds
5-MAPB is part of a broader class of benzofuran derivatives, including compounds such as 5-APB, 6-APB, and 5-EAPB. These substances share structural similarities and are known to produce comparable entactogenic effects.
Legal Status
The legal status of 5-MAPB varies internationally:
- United States: While it is not explicitly scheduled, it may be considered an analogue of MDMA, potentially subjecting it to regulation under the Federal Analogue Act.
- United Kingdom: 5-MAPB was classified as a Class B drug on June 10, 2014, making its production, distribution, and possession illegal.
- Canada: Although not specifically listed in the Controlled Drugs and Substances Act, its structural similarity to MDMA could imply analogous legal restrictions.
- China: As of October 2015, 5-MAPB is a controlled substance.
Safety Considerations
Due to limited research on This chemical, its safety profile is not well-defined. Potential risks include neurotoxicity, cardiovascular effects, and serotonin syndrome, especially when combined with other serotonergic substances. Users are advised to exercise caution and prioritize harm reduction practices.
Conclusion
5-MAPB is a synthetic entactogen with pharmacological effects similar to MDMA. However, due to its unclear legal status in many jurisdictions and limited research on its safety and efficacy, individuals should approach this compound with caution and remain informed about the potential risks and legal implications associated with its use.




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