5F-CUMYL-PEGACLONE

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Category: CANNABINOIDS Tag: buy 5f-SGT-151

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5F-CUMYL-PEGACLONE — Chemistry, Pharmacology, Effects, and Safety Overview

Introduction

One such novel psychoactive substance (NPS) is 5F-CUMYL-PEGACLONE, a potent synthetic cannabinoid receptor agonist. This compound, first identified in drug seizures in 2018, has attracted attention due to its potent effects and health risks. This article provides a comprehensive review of 5F-CUMYL-PEGACLONE, covering its chemical structure, pharmacology, effects, dosage, analogues, safety concerns, and conclusions on its potential impact. Order Now

Chemical Structure

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IUPAC Name:
1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide

Molecular Formula:
C23H26FN3O

Molecular Weight:
379.5 g/mol

Structure Overview:
5F-CUMYL-PEGACLONE is a member of the γ-carboline class of synthetic cannabinoids. It features:

A γ-carboline (pyrrolo[3,2-c]pyridine) core structure
A 5-fluoropentyl side chain attached to the nitrogen atom
A cumyl (2-phenylpropan-2-yl) group linked via a carboxamide bridge

The presence of the fluorine atom enhances the compound’s lipophilicity and potency at cannabinoid receptors.

Structural Similarity:
It shares a structural resemblance with other synthetic cannabinoids like CUMYL-PEGACLONE, but with a fluorinated alkyl side chain, which significantly influences its pharmacological properties.

Pharmacology

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Mechanism of Action:
It acts as a potent full agonist of the CB1 and CB2 cannabinoid receptors. Unlike naturally occurring cannabinoids such as Δ9-THC (a partial agonist), synthetic cannabinoids like 5F-CUMYL-PEGACLONE exert greater binding affinity and intrinsic activity at these receptors.

Binding Affinity:
Although precise Ki values are not consistently reported, synthetic cannabinoids of this class typically exhibit nanomolar to sub-nanomolar affinity for CB1 receptors, contributing to their potent psychoactive and physiological effects.

Pharmacokinetics:
Limited in vivo data exists, but like other lipophilic cannabinoids:

Rapid onset of action (within minutes when smoked)
High volume of distribution
Metabolized primarily by the liver through hydroxylation and carboxylation
Excreted via urine, detectable through specialized toxicology assays

Effects

Desired Effects:
Users report effects similar to potent cannabis derivatives, including:

Euphoria
Altered perception of time and space
Enhanced sensory experiences
Deep sedation or relaxation

Adverse Effects:
Due to its high potency and full agonist activity, It is associated with a range of severe side effects:

Acute anxiety, paranoia
Hallucinations, confusion
Nausea, vomiting
Cardiovascular effects (tachycardia, hypertension)
Seizures
Loss of consciousness or coma at high doses

Dosage and Administration

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Routes of Administration:

Inhalation (smoked or vaporized, typically sprayed onto plant material)
Oral ingestion (rare)

Dosage:
There are no medically approved dosages. Anecdotal user reports suggest that even milligram or sub-milligram doses can be highly active. The compound’s potency increases the risk of accidental overdose.

Note: Due to the lack of regulated preparations and quality control, precise dosing is highly unpredictable and dangerous.

Analogues and Related Compounds

It is chemically and pharmacologically related to:

CUMYL-PEGACLONE (non-fluorinated analogue)
5F-CUMYL-PINACA
CUMYL-PINACA
Other fluorinated alkyl chain synthetic cannabinoids

These analogues differ by side chain length, halogen substitutions, and core structures but generally share high CB1 receptor activity and associated risks.

Safety Considerations

Toxicity:
Synthetic cannabinoids of this class have been implicated in numerous cases of:

Acute intoxication
Seizures
Fatal overdoses

Legal Status:
As of 2024:

Controlled in many countries under new psychoactive substance legislation (e.g., Schedule I substance in the USA, Class B/C in the UK, and similar restrictions in the EU)
Often subject to emergency bans due to public health threats

Health Risks:
It presents risks of:

Neurotoxicity
Cardiovascular collapse
Psychosis
Severe withdrawal symptoms upon repeated use

Conclusion

5F-CUMYL-PEGACLONE represents a highly potent and dangerous synthetic cannabinoid with significant public health implications. Its pharmacological activity as a full CB1 receptor agonist, coupled with its unpredictable dosing and severe adverse effects, makes it a substance of concern for both recreational users and health authorities. Continued research, forensic monitoring, and public awareness campaigns are essential to address the ongoing challenges posed by synthetic cannabinoids like 5F-CUMYL-PEGACLONE.

📌 Disclaimer:

This article is intended for educational, toxicological, and forensic purposes only. The use, possession, or distribution of 5F-CUMYL-PEGACLONE may be illegal and poses significant health risks.