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There are no studies that have been conducted on potential abuse in humans.Pentetrone, a derivative of substituted phenol, was initially identified in 2010 as one of the various forms of bath salts available in the United States and the United Kingdom. Pentadrene is a member of the cathinone class. Users of pentadrene have reported experiencing MDMA-like stimulating effects, including euphoria, increased sociability, and sexual drive.

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Pentedrone, a pure Tran selective receptor blocker, does not elicit monoamine release, but it preferentially inhibits the release of dopamine and noradrenaline with minimal effects on the release of oxytocin.

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Pentedrone, often referred to as α-methylamino-valerophenone, is a catehinone class stimulant that has been used as a designer drug since 2010 and has been discovered as an ingredient in several “bath salt” mixes that are sold as legal height enhancers.

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Here’s an article on Pentedrone, covering its description, qualities, features, analogs, and usage instructions.

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Pentedrone: A Synthetic Cathinone with Stimulant Properties

Introduction

Pentedrone is a synthetic stimulant belonging to the cathinone class, which is chemically related to amphetamines. It has been used as a research chemical and has gained notoriety as a component in illicit drug markets. Pentedrone is known for its stimulant and euphoric effects, making it popular in recreational settings. However, due to its potential health risks and legal status in many countries, its use is heavily regulated.

Chemical Qualities and Features

• IUPAC Name: 2-(Methylamino)-1-phenylpentan-1-one
• Molecular Formula: C12H17NO
• Molecular Weight: 191.27 g/mol
• Structural Class: Synthetic cathinone
• Appearance: Typically found as a white crystalline powder
• Solubility: Soluble in water and alcohol-based solvents
• Mechanism of Action: Like other cathinones, pentedrone acts as a dopamine-norepinephrine reuptake inhibitor (DNRI), increasing levels of these neurotransmitters in the brain, leading to heightened alertness and stimulation.

Effects and Risks

Desired Effects:

• Increased energy and wakefulness
• Enhanced focus and motivation
• Feelings of euphoria
• Mild appetite suppression

Side Effects and Risks:

• Increased heart rate and blood pressure
• Anxiety, paranoia, and agitation
• Insomnia and restlessness
• Potential neurotoxicity with high or prolonged use
• Risk of addiction and withdrawal symptoms

Due to these effects, pentedrone is considered a potentially harmful substance, particularly when used in uncontrolled environments.

Analog Compounds (Related Chemicals)

Pentedrone is chemically similar to other synthetic cathinones, including:

1. Mephedrone (4-MMC): A popular synthetic cathinone with stimulant and empathogenic effects.
2. Methcathinone: A structurally related stimulant, sometimes referred to as “cat” or “Jeff.”
3. α-PVP (Flakka): A potent stimulant with effects similar to methamphetamine.
4. Ethylone: Another cathinone that produces euphoria and stimulation, similar to MDMA.
5. 4-MPD (4-Methylpentedrone): A methylated analog of pentedrone with comparable stimulant properties.

Due to the legal restrictions placed on pentedrone, many of these analogs have emerged as substitutes in the illicit market.

Usage Instructions and Precautions

Medical and Research Usage

Pentedrone does not have any officially recognized medical use. However, it has been studied for its pharmacological effects in neuroscience and forensic toxicology.

Illicit Use and Legal Status

• Pentedrone has been banned or controlled in several countries, including the United States, Canada, the UK, and most European nations due to its potential for abuse.
• It is often sold under misleading names or mixed with other substances, increasing the risk of overdose and unpredictable effects.

Harm Reduction Measures

If encountering pentedrone in a research setting, the following precautions should be taken:

• Avoid high doses due to the risk of severe side effects.
• Do not mix with other stimulants, alcohol, or depressants.
• Ensure proper identification through chemical reagent tests to avoid consuming unknown substances.
• Seek medical attention if experiencing adverse reactions such as severe agitation, hallucinations, or heart palpitations.

Conclusion

Pentedrone is a powerful stimulant with effects similar to amphetamines and other cathinones. While it has been used in research, its presence in illicit drug markets and potential for abuse make it a high-risk substance. Its similarity to other banned stimulants has led to global regulatory measures aimed at reducing harm. Those who encounter pentedrone, whether in a laboratory or illicit context, should approach it with caution and be aware of its legal and health implications.

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