m-CPP (meta-Chlorophenylpiperazine): Composition, Specifications, and Uses
Introduction
Meta-Chlorophenylpiperazine (m-CPP) is a psychoactive drug that belongs to the phenylpiperazine class of compounds. It is a derivative of piperazine with stimulant and serotonergic properties and has been studied for its effects on neurotransmitter systems, particularly serotonin. It is often used in pharmacological research and was previously found as an adulterant in some illicit drugs.
Chemical Composition and Ingredients
- Chemical Name: 1-(3-Chlorophenyl)piperazine
- Molecular Formula: C10H13ClN2
- Molecular Weight: 196.68 g/mol
- Chemical Structure: Contains a piperazine ring attached to a meta-positioned chlorophenyl group
Specifications
- Appearance: White to off-white crystalline powder
- Solubility: Soluble in water, ethanol, and other organic solvents
- Purity: Typically available at ≥ 98% purity
- Melting Point: 210-215°C
- Boiling Point: Not readily available due to decomposition at high temperatures
- Density: Approximately 1.2 g/cm³
- pH (aqueous solution): Slightly basic
Description and Uses
m-CPP is known for its effects on serotonin receptors, particularly as an agonist at 5-HT2C, 5-HT2B, and 5-HT2A receptors. It has been studied in clinical and preclinical research for its influence on mood, appetite, and anxiety. Some key points about its applications include:
- Pharmaceutical Research: Researchers have explored m-CPP as a potential drug candidate for treating mood disorders, but regulatory authorities have not widely approved it for therapeutic use.
- Psychoactive Effects: It produces stimulant-like effects, including anxiety, dizziness, and changes in body temperature regulation.
- Adulterant in Illicit Drugs: Found as a contaminant in ecstasy tablets, leading to unwanted side effects.
- Neurochemical Studies: Used to study serotonin pathways and their role in psychiatric disorders.
Safety and Handling
- Toxicity: Known to cause nausea, dizziness, and increased anxiety in some individuals.
- Storage Conditions: Store in a cool, dry place, away from light and moisture.
- Regulation: Depending on the country, it may be classified as a controlled substance or a research chemical.
Conclusion
m-CPP is a synthetic compound with significant pharmacological interest, particularly in serotonin research. While it has been explored for potential therapeutic applications, its adverse effects and stimulant-like properties have limited its clinical use. Proper handling and regulatory compliance are essential when working with this compound.
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