SLU-PP-332 for Sale (ERRα Agonist)

SLU-PP-332 for Sale in the U.S. The estrogen-related receptor alpha (ERR) is frequently used in biomedical research to investigate mitochondrial function and energy homeostasis. Our SLU-PP-332 for sale is a powerful and selective agonist of ERR. This chemical is useful for studying metabolism, aging, and related diseases because it stimulates gene transcription linked to metabolic processes. Structure-activity studies focused on ERR led to the development of SLU-PP-332, which has high receptor selectivity and low off-target effects. It is suitable for both in vitro and in vivo experiments due to its capacity to upregulate pathways involved in oxidative metabolism and mitochondrial biogenesis. Shop Now

Technical & Research Biology

A chemical probe, the SLU-PP-332, is available for purchase. It can detect ERR activity and provide insight into metabolic regulation. For the nuclear receptor ERR, which lacks an endogenous ligand, SLU-PP-332 is a reliable synthetic agonist.

It has been demonstrated to:
Enhance mitochondrial gene expression.
Increase the cellular energy output.
Support research on metabolic illness models, such as obesity and type 2 diabetes.
Learn more about how ERR affects how the heart, brown adipose tissue, and skeletal muscle work. Researchers attempting to comprehend the molecular mechanisms underlying energy metabolism and mitochondrial function rely heavily on this chemical.

Storage

SLU-PP-332 for Sale online

To ensure long-term stability and integrity of SLU-PP-332, follow the specified storage conditions.
-20°C is the storage temperature. Handling: Keep out any moisture or air. Sensitivity to Light: Keep it in a dark container or cover it from light. Shelf Life: Stable for at least one year when stored in the right conditions. Whether researching mitochondrial physiology or ERRα-related pathways, slu-pp-332 is a dependable reagent that provides consistent, high-purity results.

SLU-PP-332 for Sale in the U.S.

SLU-PP-332 is a synthetic compound recognized for its role as a pan-agonist of the estrogen receptor-related receptors (ERRs), specifically targeting ERRα, ERRβ, and ERRγ. Among these, it exhibits the highest potency for ERRα, with EC₅₀ values of 98 nM for ERRα, 230 nM for ERRβ, and 430 nM for ERRγ. 

Chemical Structure and Properties

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Chemically known as (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide, SLU-PP-332 has a molecular weight of 290.32 and a molecular formula of C₁₈H₁₄N₂O₂. It is soluble in dimethyl sulfoxide (DMSO) up to 100 mM and is typically stored at -20°C to maintain its stability. 

Biological Activity and Research Findings

SLU-PP-332 has been shown to enhance mitochondrial function and cellular respiration in skeletal muscle cell lines. In vivo studies involving mice demonstrated that administration of SLU-PP-332 led to an increase in type IIa oxidative skeletal muscle fibers and improved exercise endurance. The activation of an ERRα-specific acute aerobic exercise genetic program causes these effects, indicating the compound’s potential as an exercise mimetic. 

Further research in mouse models of metabolic syndrome has shown that SLU-PP-332 administration not only mimics exercise-induced benefits on whole-body metabolism but also enhances energy expenditure and fatty acid oxidation. Moreover, these changes were accompanied by a significant reduction in fat mass accumulation as well as improved insulin sensitivity. Therefore, the pharmacological activation of ERRs by SLU-PP-332 may represent an effective strategy for treating metabolic disorders while simultaneously enhancing muscle function during aging.

Potential Therapeutic Applications

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SLU-PP-332’s activation of ERRs and exercise-like effects make it a strong candidate for treating metabolic diseases, obesity, and exercise-related conditions. Its ability to boost mitochondrial function and oxidative muscle fibers highlights its potential for enhancing muscle performance and metabolic health.

Conclusion

SLU-PP-332 represents a significant advancement in the field of metabolic research, offering insights into the modulation of ERRs and their impact on energy metabolism and exercise physiology. Researchers expect ongoing studies to further elucidate its mechanisms and therapeutic potential in various metabolic and age-related conditions.